A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells

A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells

Many tumor cells produce vast amounts of lactate and acid, which have to be removed from the cell to prevent intracellular lactacidosis and suffocation of metabolism. In the present study, we show that proton-driven lactate flux is enhanced by the intracellular carbonic anhydrase CAII, which is colo...

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Bibliographic Details
Main Authors: Sina Ibne Noor, Somayeh Jamali, Samantha Ames, Silke Langer, Joachim W Deitmer, Holger M Becker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-05-01
Series:eLife
Subjects:
monocarboxylate transporter
proton antenna
hypoxia
breast cancer cells
proton-sensitive micro electrodes
pH imaging
Online Access:https://elifesciences.org/articles/35176

Internet

https://elifesciences.org/articles/35176

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