A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective Autophagy via the PDK1/Akt Signaling Pathway in Non-Small Cell Lung Cancer

A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective Autophagy via the PDK1/Akt Signaling Pathway in Non-Small Cell Lung Cancer

In a preliminary study, we synthesized a series of new PDK1/MEK dual inhibitors. Antitumor activity screening showed that Compound YZT exerts a strong inhibitory action in A549 cells. However, the specific mechanism of YZT against non-small cell lung cancer (NSCLC) is largely unknown. This work conf...

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Bibliographic Details
Main Authors: Rangru Liu, Zhuo Chen, Gaoyun Hu, Zutao Yu, Qianbin Li, Danqi Liu, Ling Li, Zhaoqian Liu
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
compound YZT
a PDK1/MEK dual inhibitor
the PDK1/Akt pathway
autophagy
apoptosis
Online Access:https://www.mdpi.com/1424-8247/16/2/244

Internet

https://www.mdpi.com/1424-8247/16/2/244

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