Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media

Essential Role of the Innate Immune Adaptor RIP2 in the Response to Otitis Media

Intracellular nucleotide binding and oligomerization domain (NOD) and Toll-like (TLR) receptors have emerged as pivotal sensors of infection. Both Nod1 and Nod2 contain a caspase activation and recruitment domain (CARD) that interacts with the adaptor protein RIP2 (receptor-interaction protein-2). T...

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Bibliographic Details
Main Authors: Arwa Kurabi, Jasmine Lee, Kwang Pak, Anke Leichtle, Allen F Ryan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Genetics
Subjects:
receptor interacting protein 2 (RIP2)
inflammation
pro-inflammatory cytokines
ear infections
TLR—toll-like receptor
NLR (NOD-like receptors)
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.893085/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2022.893085/full

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