Reversion of in vivo fibrogenesis by novel chromone scaffoldsReseach in context

Background: Myofibroblasts are known to play a key role in the development of idiopathic pulmonary fibrosis (IPF). Two drugs, pirfenidone and nintedanib, are the only approved therapeutic options for IPF, but their applications are limited due to their side effects. Thus, curative IPF drugs represen...

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Bibliographic Details
Main Authors: Han-Soo Kim, Young-Min Yoon, Moon Kee Meang, Yae Eun Park, Ji Yong Lee, Tae Hee Lee, Ji Eun Lee, Ik-Hwan Kim, Byung-Soo Youn
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396418305942