Reverse and Forward Electron Flow-Induced H<sub>2</sub>O<sub>2</sub> Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals

Reverse and Forward Electron Flow-Induced H<sub>2</sub>O<sub>2</sub> Formation Is Decreased in α-Ketoglutarate Dehydrogenase (α-KGDH) Subunit (E2 or E3) Heterozygote Knock Out Animals

α-ketoglutarate dehydrogenase complex (KGDHc), or 2-oxoglutarate dehydrogenase complex (OGDHc) is a rate-limiting enzyme in the tricarboxylic acid cycle, that has been identified in neurodegenerative diseases such as in Alzheimer’s disease. The aim of the present study was to establish the role of t...

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Bibliographic Details
Main Authors: Gergő Horváth, Gergely Sváb, Tímea Komlódi, Dora Ravasz, Gergely Kacsó, Judit Doczi, Christos Chinopoulos, Attila Ambrus, László Tretter
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
KGDHc
α-ketoglutarate dehydrogenase complex
OGDHc
oxoglutarate dehydrogenase complex
ischemia-reperfusion
antioxidant systems
Online Access:https://www.mdpi.com/2076-3921/11/8/1487

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https://www.mdpi.com/2076-3921/11/8/1487

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