Structural mechanism of ligand activation in human calcium-sensing receptor

Structural mechanism of ligand activation in human calcium-sensing receptor

Human calcium-sensing receptor (CaSR) is a G-protein-coupled receptor (GPCR) that maintains extracellular Ca2+ homeostasis through the regulation of parathyroid hormone secretion. It functions as a disulfide-tethered homodimer composed of three main domains, the Venus Flytrap module, cysteine-rich d...

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Bibliographic Details
Main Authors: Yong Geng, Lidia Mosyak, Igor Kurinov, Hao Zuo, Emmanuel Sturchler, Tat Cheung Cheng, Prakash Subramanyam, Alice P Brown, Sarah C Brennan, Hee-chang Mun, Martin Bush, Yan Chen, Trang X Nguyen, Baohua Cao, Donald D Chang, Matthias Quick, Arthur D Conigrave, Henry M Colecraft, Patricia McDonald, Qing R Fan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
calcium-sensing receptor
extracellular calcium homeostasis
principal agonist
amino acids
extracellular domain structure
receptor activation mechanism
Online Access:https://elifesciences.org/articles/13662

Internet

https://elifesciences.org/articles/13662

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