Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase.

Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase.

The oncogenic fusion protein RUNX1-ETO is a product of the t(8;21) translocation and consists of the hematopoietic transcriptional master regulator RUNX1 and the repressor ETO. RUNX1-ETO is found in 10-15% of acute myeloid leukemia and interferes with the expression of genes that are essential for m...

Full description

Bibliographic Details
Main Authors: Caroline Schoenherr, Katharina Wohlan, Iris Dallmann, Andreas Pich, Jan Hegermann, Arnold Ganser, Denise Hilfiker-Kleiner, Olaf Heidenreich, Michaela Scherr, Matthias Eder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0225977

Internet

https://doi.org/10.1371/journal.pone.0225977

Similar Items