Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts

Impact of the Breakpoint Region on the Leukemogenic Potential and the TKI Responsiveness of Atypical BCR-ABL1 Transcripts

Chronic Myeloid Leukemia (CML) is a hematological disorder characterized by the clonal expansion of a hematopoietic stem cell carrying the Philadelphia chromosome that juxtaposes the BCR and ABL1 genes. The ensuing BCR-ABL1 chimeric oncogene is characterized by a breakpoint region that generally inv...

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Bibliographic Details
Main Authors: Michele Massimino, Elena Tirrò, Stefania Stella, Livia Manzella, Maria Stella Pennisi, Chiara Romano, Silvia Rita Vitale, Adriana Puma, Cristina Tomarchio, Sandra Di Gregorio, Agostino Antolino, Francesco Di Raimondo, Paolo Vigneri
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
CML
BCR-ABL1 fusion transcripts
TKIs
nilotinib
DC2
SH3
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.669469/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.669469/full

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