Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement

Functional optic tract rewiring via subtype- and target-specific axonal regeneration and presynaptic activity enhancement

Abstract Mechanisms underlying functional axonal rewiring after adult mammalian central nervous system (CNS) injuries remain unclear partially due to limited models. Here we develop a mouse intracranial pre–olivary pretectal nucleus (OPN) optic tract injury model and demonstrate that Pten/Socs3 knoc...

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Bibliographic Details
Main Authors: Xin Zhang, Chao Yang, Chengle Zhang, Junqiang Wu, Xiang Zhang, Jiayang Gao, Xuejie Wang, Leung Ting Chan, Yiren Zhou, Yujun Chen, Sindy Sing Ting Tam, Shuhang Chen, Yuqian Ma, Wing-Ho Yung, Liting Duan, Liwen Jiang, Yiwen Wang, Kai Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57445-x

Internet

https://doi.org/10.1038/s41467-025-57445-x

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