An ROR1 bi-specific T-cell engager provides effective targeting and cytotoxicity against a range of solid tumors

An ROR1 bi-specific T-cell engager provides effective targeting and cytotoxicity against a range of solid tumors

We have developed a humanized bi-specific T-cell engager (BiTE) targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1), a cell surface antigen present on a range of malignancies and cancer-initiating cells. Focusing initially on pancreatic cancer, we demonstrated that our ROR1 BiTE results...

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Bibliographic Details
Main Authors: Satyen Harish Gohil, Solange Rosa Paredes-Moscosso, Micaela Harrasser, Marzia Vezzalini, Aldo Scarpa, Emma Morris, Andrew M. Davidoff, Claudio Sorio, Amit Chunilal Nathwani, Marco Della Peruta
Format: Article
Language:English
Published: Taylor & Francis Group 2017-07-01
Series:OncoImmunology
Subjects:
cancer
immunotherapy
ror1
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1326437

Internet

http://dx.doi.org/10.1080/2162402X.2017.1326437

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