Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress.

Increased miltefosine tolerance in clinical isolates of Leishmania donovani is associated with reduced drug accumulation, increased infectivity and resistance to oxidative stress.

BACKGROUND:Miltefosine (MIL) is an oral antileishmanial drug used for treatment of visceral leishmaniasis (VL) in the Indian subcontinent. Recent reports indicate a significant decline in its efficacy with a high rate of relapse in VL as well as post kala-azar dermal leishmaniasis (PKDL). We investi...

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Bibliographic Details
Main Authors: Deepak Kumar Deep, Ruchi Singh, Vasundhra Bhandari, Aditya Verma, Vanila Sharma, Saima Wajid, Shyam Sundar, V Ramesh, Jean Claude Dujardin, Poonam Salotra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-06-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5470736?pdf=render

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http://europepmc.org/articles/PMC5470736?pdf=render

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