Targeting SOX18 Transcription Factor Activity by Small-Molecule Inhibitor Sm4 in Non-Small Lung Cancer Cell Lines

Targeting SOX18 Transcription Factor Activity by Small-Molecule Inhibitor Sm4 in Non-Small Lung Cancer Cell Lines

The transcription factor SOX18 has been shown to play a crucial role in lung cancer progression and metastasis. In this study, we investigated the effect of Sm4, a SOX18 inhibitor, on cell cycle regulation in non-small cell lung cancer (NSCLC) cell lines LXF-289 and SK-MES-1, as well as normal human...

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Bibliographic Details
Main Authors: Olga Rodak, Monika Mrozowska, Agnieszka Rusak, Agnieszka Gomułkiewicz, Aleksandra Piotrowska, Mateusz Olbromski, Marzenna Podhorska-Okołów, Maciej Ugorski, Piotr Dzięgiel
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
non-small lung cancer
adenocarcinoma
squamous carcinoma
transcription factors
SOX18
p21
Online Access:https://www.mdpi.com/1422-0067/24/14/11316

Internet

https://www.mdpi.com/1422-0067/24/14/11316

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