Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice

Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice

Abstract Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-β1 is implicated in this activation. In this study, we screened for chemicals capable of inhibiting TGF-β1-induced colla...

Full description

Bibliographic Details
Main Authors: Ken-ichiro Tanaka, Tomomi Niino, Tomoaki Ishihara, Ayaka Takafuji, Takahiro Takayama, Yuki Kanda, Toshifumi Sugizaki, Fumiya Tamura, Shota Kurotsu, Masahiro Kawahara, Tohru Mizushima
Format: Article
Language:English
Published: Nature Portfolio 2017-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-03676-y

Internet

https://doi.org/10.1038/s41598-017-03676-y

Similar Items