ATP-evoked intracellular Ca2+ transients shape the ionic permeability of human microglia from epileptic temporal cortex

ATP-evoked intracellular Ca2+ transients shape the ionic permeability of human microglia from epileptic temporal cortex

Abstract Background Intracellular Ca2+ modulates several microglial activities, such as proliferation, migration, phagocytosis, and inflammatory mediator secretion. Extracellular ATP, the levels of which significantly change during epileptic seizures, activates specific receptors leading to an incre...

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Bibliographic Details
Main Authors: Nicole Piera Palomba, Katiuscia Martinello, Germana Cocozza, Sara Casciato, Addolorata Mascia, Giancarlo Di Gennaro, Roberta Morace, Vincenzo Esposito, Heike Wulff, Cristina Limatola, Sergio Fucile
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Neuroinflammation
Subjects:
Temporal lobe epilepsy
KCa3.1
Neuroinflammation
Purinergic signaling
Primary cultures
Perforated patch
Online Access:https://doi.org/10.1186/s12974-021-02096-0

Internet

https://doi.org/10.1186/s12974-021-02096-0

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