Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [<sup>11</sup>C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier

Impact of Cytochrome Induction or Inhibition on the Plasma and Brain Kinetics of [<sup>11</sup>C]metoclopramide, a PET Probe for P-Glycoprotein Function at the Blood-Brain Barrier

[<sup>11</sup>C]metoclopramide PET imaging provides a sensitive and translational tool to explore P-glycoprotein (P-gp) function at the blood-brain barrier (BBB). Patients with neurological diseases are often treated with cytochrome (CYP) modulators which may impact the plasma and brain...

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Bibliographic Details
Main Authors: Louise Breuil, Nora Ziani, Sarah Leterrier, Gaëlle Hugon, Fabien Caillé, Viviane Bouilleret, Charles Truillet, Maud Goislard, Myriam El Biali, Martin Bauer, Oliver Langer, Sébastien Goutal, Nicolas Tournier
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
ATP-binding cassette
drug–drug interaction
membrane transporter
neuropharmacology
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/14/12/2650

Internet

https://www.mdpi.com/1999-4923/14/12/2650

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