Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia

Purinoreceptors and ectonucleotidases control ATP-induced calcium waveforms and calcium-dependent responses in microglia: Roles of P2 receptors and CD39 in ATP-stimulated microglia

Adenosine triphosphate (ATP) and its metabolites drive microglia migration and cytokine production by activating P2X- and P2Y- class purinergic receptors. Purinergic receptor activation gives rise to diverse intracellular calcium (Ca2+ signals, or waveforms, that differ in amplitude, duration, and f...

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Bibliographic Details
Main Authors: Byeong J. Chun, Surya P. Aryal, Peter Varughese, Bin Sun, Joshua A. Bruno, Chris I. Richards, Adam D. Bachstetter, Peter M. Kekenes-Huskey
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Physiology
Subjects:
cells-monocytes/macrophages
processes-cell activation
processes-chemotaxis
processes-inflammation
processes-signal transduction
calcium
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1037417/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.1037417/full

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