Global early replication disrupts gene expression and chromatin conformation in a single cell cycle
Abstract Background The early embryonic divisions of many organisms, including fish, flies, and frogs, are characterized by a very rapid S-phase caused by high rates of replication initiation. In somatic cells, S-phase is much longer due to both a reduction in the total number of initiation events a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-022-02788-7 |