A versatile, fast and unbiased method for estimation of gene-by-environment interaction effects on biobank-scale datasets

A versatile, fast and unbiased method for estimation of gene-by-environment interaction effects on biobank-scale datasets

Abstract Identification of gene-by-environment interactions (GxE) is crucial to understand the interplay of environmental effects on complex traits. However, current methods evaluating GxE on biobank-scale datasets have limitations. We introduce MonsterLM, a multiple linear regression method that do...

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Bibliographic Details
Main Authors: Matteo Di Scipio, Mohammad Khan, Shihong Mao, Michael Chong, Conor Judge, Nazia Pathan, Nicolas Perrot, Walter Nelson, Ricky Lali, Shuang Di, Robert Morton, Jeremy Petch, Guillaume Paré
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40913-7

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https://doi.org/10.1038/s41467-023-40913-7

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