Immune Checkpoint Inhibitors for the Treatment of Central Nervous System (CNS) Metastatic Disease

Immune Checkpoint Inhibitors for the Treatment of Central Nervous System (CNS) Metastatic Disease

While the CNS has long been viewed as an immune-privileged environment, a paradigm shift in neuro-immunology has elevated the role of systemic immunotherapy for the treatment of metastatic disease. Increasing knowledge regarding the presence of a CNS lymphatic system and the physical and biochemical...

Full description

Bibliographic Details
Main Authors: Suneel D. Kamath, Priya U. Kumthekar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Oncology
Subjects:
immunotherapy
brain metastasis
CNS metastasis
checkpoint inhibitors
PD-1
pembrolizumab
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00414/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00414/full

Similar Items