Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in Uganda

Spike Protein Cleavage-Activation in the Context of the SARS-CoV-2 P681R Mutation: an Analysis from Its First Appearance in Lineage A.23.1 Identified in Uganda

ABSTRACT Based on its predicted ability to affect transmissibility and pathogenesis, surveillance studies have highlighted the role of a specific mutation (P681R) in the S1/S2 furin cleavage site of the SARS-CoV-2 spike protein. Here we analyzed A.23.1, first identified in Uganda, as a P681R-contain...

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Bibliographic Details
Main Authors: Bailey Lubinski, Laura E. Frazier, My V. T. Phan, Daniel L. Bugembe, Jessie L. Cunningham, Tiffany Tang, Susan Daniel, Matthew Cotten, Javier A. Jaimes, Gary R. Whittaker
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:Microbiology Spectrum
Subjects:
A.23.1
P681R mutation
SARS-CoV-2
spike
Uganda
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01514-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.01514-22

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