Antigen-independent IFN-γ production by human naïve CD4 T cells activated by IL-12 plus IL-18.

Antigen-independent IFN-γ production by human naïve CD4 T cells activated by IL-12 plus IL-18.

The role of T cells in innate immunity is not well defined. In this report, we show that a subset of human peripheral blood CD4(+) T cells responds to IL-12 plus IL-18, but not to IL-12 or IL-18 alone, by producing IFN-γ in the absence of any antigenic stimulation or cell proliferation. Intracellula...

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Bibliographic Details
Main Authors: Rachel B Munk, Katsuki Sugiyama, Paritosh Ghosh, Carl Y Sasaki, Louis Rezanka, Kasturi Banerjee, Hidenori Takahashi, Ranjan Sen, Dan L Longo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3091853?pdf=render

Internet

http://europepmc.org/articles/PMC3091853?pdf=render

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