Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly

Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly

SUV39H is the major histone H3 lysine 9 (H3K9)-specific methyltransferase that targets pericentric regions and is crucial for assembling silent heterochromatin. SUV39H recognizes trimethylated H3K9 (H3K9me3) via its chromodomain (CD), and enriched H3K9me3 allows SUV39H to target specific chromosomal...

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Bibliographic Details
Main Authors: Atsuko Shirai, Takayuki Kawaguchi, Hideaki Shimojo, Daisuke Muramatsu, Mayumi Ishida-Yonetani, Yoshifumi Nishimura, Hiroshi Kimura, Jun-ichi Nakayama, Yoichi Shinkai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
Suv39h1
chromodomain
HP1
pericentromere
heterochromatin
H3K9 methylation
Online Access:https://elifesciences.org/articles/25317

Internet

https://elifesciences.org/articles/25317

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