The impact of NRG1 expressions and methylation on multifactorial Hirschsprung disease

The impact of NRG1 expressions and methylation on multifactorial Hirschsprung disease

Abstract Background Hirschsprung disease (HSCR) is a complex genetic disorder characterized by the lack of ganglion cells in the intestines. A current study showed that the NRG1 rare variant frequency in Indonesian patients with HSCR is only 0.9%. Here, we investigated the impact of NRG1 expressions...

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Bibliographic Details
Main Authors: Gunadi, Alvin Santoso Kalim, Marcellus, Nova Yuli Prasetyo Budi, Kristy Iskandar
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Pediatrics
Subjects:
Epigenetic
Aberrant expression
Hirschsprung disease
Methylation pattern
NRG1
Online Access:https://doi.org/10.1186/s12887-022-03287-1

Internet

https://doi.org/10.1186/s12887-022-03287-1

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