Fabrication, In Vitro and In Vivo Evaluation of Non-Ordered Mesoporous Silica-Based Ternary Solid Dispersions for Enhanced Solubility of Flurbiprofen

Fabrication, In Vitro and In Vivo Evaluation of Non-Ordered Mesoporous Silica-Based Ternary Solid Dispersions for Enhanced Solubility of Flurbiprofen

The aim of this study was to improve the solubility and prevent the ulcerogenic effect of flurbiprofen. Initially, binary and ternary solid dispersions (BSDs and TSDs) of flurbiprofen were prepared by using non-ordered mesoporous silica and gelucire. After preformulation testing (solubility, flow pr...

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Bibliographic Details
Main Authors: Muhammad Usman Munir, Mahnoor Ikraam, Muhammad Nadeem, Syed Haroon Khalid, Sajid Asghar, Ikrima Khalid, Muhammad Irfan, Nayyer Islam, Nyla Ajaz, Ikram Ullah Khan
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceuticals
Subjects:
flurbiprofen
gelucire
non-ordered mesoporous silica
ternary solid dispersion
gastric lesion index
Online Access:https://www.mdpi.com/1424-8247/15/7/856

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https://www.mdpi.com/1424-8247/15/7/856

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