Disruption of the microbiota-gut-brain axis is a defining characteristic of the α-Gal A (-/0) mouse model of Fabry disease

Disruption of the microbiota-gut-brain axis is a defining characteristic of the α-Gal A (-/0) mouse model of Fabry disease

ABSTRACTFabry disease (FD) is an X-linked metabolic disease caused by a deficiency in α-galactosidase A (α-Gal A) activity. This causes accumulation of glycosphingolipids, especially globotriaosylceramide (Gb3), in different cells and organs. Neuropathic pain and gastrointestinal (GI) symptoms, such...

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Bibliographic Details
Main Authors: C. Delprete, R. Rimondini Giorgini, E. Lucarini, T.F.S. Bastiaanssen, D. Scicchitano, N. Interino, F. Formaggio, F. Uhlig, C. Ghelardini, N.P. Hyland, J.F. Cryan, R. Liguori, M. Candela, J. Fiori, S. Turroni, L. Di Cesare Mannelli, M. Caprini
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Fabry disease
α-Gal A null mice
visceral pain
gut-brain axis
gut microbiota
short-chain fatty acids
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2256045

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https://www.tandfonline.com/doi/10.1080/19490976.2023.2256045

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