Drug Delivery through the Psoriatic Epidermal Barrier—A “Skin-On-A-Chip” Permeability Study and Ex Vivo Optical Imaging

Drug Delivery through the Psoriatic Epidermal Barrier—A “Skin-On-A-Chip” Permeability Study and Ex Vivo Optical Imaging

Psoriasis is a chronic inflammatory disease with unmet medical needs. To clarify potential therapeutic targets, different animal models have been developed. In the current study, imiquimod-induced psoriasiform dermatitis was used for monitoring the changes in skin thickness, transepidermal water los...

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Bibliographic Details
Main Authors: Dorottya Kocsis, Szabina Horváth, Ágnes Kemény, Zsófia Varga-Medveczky, Csaba Pongor, Rózsa Molnár, Anna Mihály, Dániel Farkas, Bese Márton Naszlady, András Fülöp, András Horváth, Balázs Rózsa, Erika Pintér, Rolland Gyulai, Franciska Erdő
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
psoriasis
skin permeability
skin-on-a-chip diffusion cells
TEWL
imiquimod
TRPA1 knock out
Online Access:https://www.mdpi.com/1422-0067/23/8/4237

Internet

https://www.mdpi.com/1422-0067/23/8/4237

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