Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis

Partial Inhibition of the 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 (PFKFB3) Enzyme in Myeloid Cells Does Not Affect Atherosclerosis

BackgroundThe protein 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) is a key stimulator of glycolytic flux. Systemic, partial PFKFB3 inhibition previously decreased total plaque burden and increased plaque stability. However, it is unclear which cell type conferred these positive e...

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Bibliographic Details
Main Authors: Renée J. H. A. Tillie, Jenny De Bruijn, Javier Perales-Patón, Lieve Temmerman, Yanal Ghosheh, Kim Van Kuijk, Marion J. Gijbels, Peter Carmeliet, Klaus Ley, Julio Saez-Rodriguez, Judith C. Sluimer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
myeloid cells
PFKFB3
macrophage
dendritic cell
glycolysis
atherosclerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.695684/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.695684/full

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