RocA Regulates Phosphatase Activity of Virulence Sensor CovS of Group A <italic toggle="yes">Streptococcus</italic> in Growth Phase- and pH-Dependent Manners

ABSTRACT The control of the virulence response regulator and sensor (CovR-CovS) two-component regulatory system in group A Streptococcus (GAS) strains regulates more than 15% of gene expression and has critical roles in invasive GAS infection. The membrane-embedded CovS has kinase and phosphatase ac...

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Bibliographic Details
Main Authors: Chuan Chiang-Ni, He-Jing Chiou, Huei-Chuan Tseng, Chih-Yun Hsu, Cheng-Hsun Chiu
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mSphere
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00361-20