Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Systematic underestimation of the epigenetic clock and age acceleration in older subjects

Abstract Background The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues and environments. Results The model systematically underestimates age...

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Bibliographic Details
Main Authors: Louis Y. El Khoury, Tyler Gorrie-Stone, Melissa Smart, Amanda Hughes, Yanchun Bao, Alexandria Andrayas, Joe Burrage, Eilis Hannon, Meena Kumari, Jonathan Mill, Leonard C. Schalkwyk
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Genome Biology
Subjects:
DNA methylation
Epigenetic clock
Age acceleration
Online Access:https://doi.org/10.1186/s13059-019-1810-4

Internet

https://doi.org/10.1186/s13059-019-1810-4

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