The Critical Role of The Piezo1/β‐catenin/ATF4 Axis on The Stemness of Gli1+ BMSCs During Simulated Microgravity‐Induced Bone Loss

The Critical Role of The Piezo1/β‐catenin/ATF4 Axis on The Stemness of Gli1+ BMSCs During Simulated Microgravity‐Induced Bone Loss

Abstract Disuse osteoporosis is characterized by decreased bone mass caused by abnormal mechanical stimulation of bone. Piezo1 is a major mechanosensitive ion channel in bone homeostasis. However, whether intervening in the action of Piezo1 can rescue disuse osteoporosis remains unresolved. In this...

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Bibliographic Details
Main Authors: Yuxiang Hu, Hongtao Tian, Wei Chen, Yunlu Liu, Yulin Cao, Hongxin Pei, Chaochang Ming, Cunqing Shan, Xihui Chen, Zhipeng Dai, Shuhua Yang, Zengwu Shao, Shenghui Lan, Yong Liu, Wei Tong
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Advanced Science
Subjects:
Piezo1
simulated microgravity
disuse osteoporosis
Gli1+ BMSCs
Wnt/β‐catenin/ATF4
Online Access:https://doi.org/10.1002/advs.202303375

Internet

https://doi.org/10.1002/advs.202303375

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