Composite Coatings Based on Recombinant Spidroins and Peptides with Motifs of the Extracellular Matrix Proteins Enhance Neuronal Differentiation of Neural Precursor Cells Derived from Human Induced Pluripotent Stem Cells

Composite Coatings Based on Recombinant Spidroins and Peptides with Motifs of the Extracellular Matrix Proteins Enhance Neuronal Differentiation of Neural Precursor Cells Derived from Human Induced Pluripotent Stem Cells

The production and transplantation of functionally active human neurons is a promising approach to cell therapy. Biocompatible and biodegradable matrices that effectively promote the growth and directed differentiation of neural precursor cells (NPCs) into the desired neuronal types are very importa...

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Bibliographic Details
Main Authors: Ekaterina V. Novosadova, Oleg V. Dolotov, Lyudmila V. Novosadova, Lubov I. Davydova, Konstantin V. Sidoruk, Elena L. Arsenyeva, Darya M. Shimchenko, Vladimir G. Debabov, Vladimir G. Bogush, Vyacheslav Z. Tarantul
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
composite coatings
recombinant spidroins
fused peptides with ECM motifs
induced pluripotent stem cells
neural precursor cells
dopaminergic neurons
Online Access:https://www.mdpi.com/1422-0067/24/5/4871

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https://www.mdpi.com/1422-0067/24/5/4871

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