Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation
Metformin, as a traditional oral hypoglycemic agent, is commonly used in the clinical treatment for type 2 diabetes. Recently, a large number of epidemiological researches have shown that metformin could reduce the tumor morbidity of type 2 diabetes, moreover, it has also been indicated that metform...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2013-08-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.08.07 |
| _version_ | 1818197262175567872 |
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| author | Zhaoyu CHEN Liantang WANG Yanyang CHEN |
| author_facet | Zhaoyu CHEN Liantang WANG Yanyang CHEN |
| author_sort | Zhaoyu CHEN |
| collection | DOAJ |
| description | Metformin, as a traditional oral hypoglycemic agent, is commonly used in the clinical treatment for type 2 diabetes. Recently, a large number of epidemiological researches have shown that metformin could reduce the tumor morbidity of type 2 diabetes, moreover, it has also been indicated that metformin could inhibit the growth, proliferation and transformation of cancer cells in metabolic pathways, cell cycle, oxidative stress and cancer/tumor stem cells transformation via AMPK pathway activation. But the antitumor effect of metformin via AMPK activation still exists arguments, and the definite mechanism remains to be further investigated and confirmed by extensive clinical trials. |
| first_indexed | 2024-12-12T01:47:11Z |
| format | Article |
| id | doaj.art-e68a6b71e17548bc8b51217de4a54ece |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-12T01:47:11Z |
| publishDate | 2013-08-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-e68a6b71e17548bc8b51217de4a54ece2022-12-22T00:42:34ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872013-08-0116842743210.3779/j.issn.1009-3419.2013.08.07Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated
Protein Kinase (AMPK) ActivationZhaoyu CHENLiantang WANGYanyang CHENMetformin, as a traditional oral hypoglycemic agent, is commonly used in the clinical treatment for type 2 diabetes. Recently, a large number of epidemiological researches have shown that metformin could reduce the tumor morbidity of type 2 diabetes, moreover, it has also been indicated that metformin could inhibit the growth, proliferation and transformation of cancer cells in metabolic pathways, cell cycle, oxidative stress and cancer/tumor stem cells transformation via AMPK pathway activation. But the antitumor effect of metformin via AMPK activation still exists arguments, and the definite mechanism remains to be further investigated and confirmed by extensive clinical trials.http://dx.doi.org/10.3779/j.issn.1009-3419.2013.08.07MetforminAntitumor mechanismAdenosine monophosphate-activated protein kinase (AMPK)MetabolismCell cycle arrestOxidative stressTransformation of cancer/tumor stem cells |
| spellingShingle | Zhaoyu CHEN Liantang WANG Yanyang CHEN Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated Protein Kinase (AMPK) Activation Chinese Journal of Lung Cancer Metformin Antitumor mechanism Adenosine monophosphate-activated protein kinase (AMPK) Metabolism Cell cycle arrest Oxidative stress Transformation of cancer/tumor stem cells |
| title | Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated
Protein Kinase (AMPK) Activation |
| title_full | Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated
Protein Kinase (AMPK) Activation |
| title_fullStr | Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated
Protein Kinase (AMPK) Activation |
| title_full_unstemmed | Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated
Protein Kinase (AMPK) Activation |
| title_short | Antitumor Mechanism of Metformin via Adenosine Monophosphate-activated
Protein Kinase (AMPK) Activation |
| title_sort | antitumor mechanism of metformin via adenosine monophosphate activated
protein kinase ampk activation |
| topic | Metformin Antitumor mechanism Adenosine monophosphate-activated protein kinase (AMPK) Metabolism Cell cycle arrest Oxidative stress Transformation of cancer/tumor stem cells |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2013.08.07 |
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