A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation

A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation

Meiotic sex chromosome inactivation (MSCI) is a critical feature of meiotic prophase I progression in males. While the ATR kinase and its activator TOPBP1 are key drivers of MSCI within the specialized sex body (SB) domain of the nucleus, how they promote silencing remains unclear given their multif...

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Bibliographic Details
Main Authors: Carolline Ascenção, Jennie R Sims, Alexis Dziubek, William Comstock, Elizabeth A Fogarty, Jumana Badar, Raimundo Freire, Andrew Grimson, Robert S Weiss, Paula E Cohen, Marcus B Smolka
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-02-01
Series:eLife
Subjects:
TOPBP1
ATR
meiosis
MSCI
Online Access:https://elifesciences.org/articles/90887

Internet

https://elifesciences.org/articles/90887

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