Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease

Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease

Abstract Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress made in deciphering how Huwe1 regulates neural progenitor proliferation and differen...

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Bibliographic Details
Main Authors: Andrew C. Giles, Brock Grill
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Neural Development
Subjects:
Huwe1
EEL-1
Ubiquitin ligase
HECT
Neuron
Neural progenitor
Online Access:http://link.springer.com/article/10.1186/s13064-020-00143-9

Internet

http://link.springer.com/article/10.1186/s13064-020-00143-9

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