Design and Synthesis of Helical <i>N</i>-Terminal <span style="font-variant: small-caps">l</span>-Prolyl Oligopeptides Possessing Hydrocarbon Stapling

Design and Synthesis of Helical <i>N</i>-Terminal <span style="font-variant: small-caps">l</span>-Prolyl Oligopeptides Possessing Hydrocarbon Stapling

We designed and synthesized helical short oligopeptides with an <span style="font-variant: small-caps;">l</span>-proline on the N-terminus and hydrocarbon stapling on the side chain. Side-chain stapling is a frequently used method for the development of biologically active pept...

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Bibliographic Details
Main Authors: Atsushi Ueda, Mei Higuchi, Kazuki Sato, Tomohiro Umeno, Masakazu Tanaka
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
peptide
helix
hydrocarbon stapling
ring-closing metathesis
organocatalyst
<span style="font-variant: small-caps">l</span>-proline
Online Access:https://www.mdpi.com/1420-3049/25/20/4667

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https://www.mdpi.com/1420-3049/25/20/4667

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