Identification of organs of origin of macrophages that produce presepsin via neutrophil extracellular trap phagocytosis

Identification of organs of origin of macrophages that produce presepsin via neutrophil extracellular trap phagocytosis

Abstract Presepsin (P-SEP) is a specific biomarker for sepsis. Monocytes produce P-SEP by phagocytosing neutrophil extracellular traps (NETs). Herein, we investigated whether M1 macrophages (M1 MΦs) are the primary producers of P-SEP after NET phagocytosis. We co-cultured M1 MΦs and NETs from health...

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Bibliographic Details
Main Authors: Akihiro Kondo, Tatsuya Morinishi, Yusuke Yamaguchi, Akishige Ikegame
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Scientific Reports
Subjects:
Presepsin
Macrophage
Neutrophil extracellular traps
Sepsis
Biomarker
Online Access:https://doi.org/10.1038/s41598-024-66916-y

Internet

https://doi.org/10.1038/s41598-024-66916-y

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