Non-Apoptotic Caspase-3 Activation Mediates Early Synaptic Dysfunction of Indirect Pathway Neurons in the Parkinsonian Striatum

Non-Apoptotic Caspase-3 Activation Mediates Early Synaptic Dysfunction of Indirect Pathway Neurons in the Parkinsonian Striatum

Non-apoptotic caspase-3 activation is critically involved in dendritic spine loss and synaptic dysfunction in Alzheimer’s disease. It is, however, not known whether caspase-3 plays similar roles in other pathologies. Using a mouse model of clinically manifest Parkinson’s disease, we provide the firs...

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Bibliographic Details
Main Authors: Tim Fieblinger, Chang Li, Elena Espa, M. Angela Cenci
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
Parkinson’s disease
striatum
caspase-3
spiny projection neurons
dendritic spines
long-term depression
Online Access:https://www.mdpi.com/1422-0067/23/10/5470

Internet

https://www.mdpi.com/1422-0067/23/10/5470

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