DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer

Abstract Background High expression of immune checkpoints in tumor microenvironment plays significant roles in inhibiting anti-tumor immunity, which is associated with poor prognosis and cancer progression. Major epigenetic modifications in both DNA and histone could be involved in upregulation of i...

Full description

Bibliographic Details
Main Authors: Varun Sasidharan Nair, Haytham El Salhat, Rowaida Z. Taha, Anne John, Bassam R. Ali, Eyad Elkord
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Clinical Epigenetics
Subjects:
Breast cancer
Immune checkpoints
PD-L1
DNA methylation
Histone trimethylation
Online Access:http://link.springer.com/article/10.1186/s13148-018-0512-1

Internet

http://link.springer.com/article/10.1186/s13148-018-0512-1

Similar Items