In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds

In Silico Analysis of the Multi-Targeted Mode of Action of Ivermectin and Related Compounds

Some clinical studies have indicated activity of ivermectin, a macrocyclic lactone, against COVID-19, but a biological mechanism initially proposed for this anti-viral effect is not applicable at physiological concentrations. This in silico investigation explores potential modes of action of ivermec...

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Bibliographic Details
Main Authors: Maral Aminpour, Marco Cannariato, Jordane Preto, M. Ehsan Safaeeardebili, Alexia Moracchiato, Domiziano Doria, Francesca Donato, Eric Adriano Zizzi, Marco Agostino Deriu, David E. Scheim, Alessandro D. Santin, Jack Adam Tuszynski
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Computation
Subjects:
alpha-7 nicotinic receptor
CD147
docking
ivermectin
molecular modeling
SARS-CoV-2
Online Access:https://www.mdpi.com/2079-3197/10/4/51

Internet

https://www.mdpi.com/2079-3197/10/4/51

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