PEG-Modified <i>tert</i>-Octylcalix[8]arenes as Drug Delivery Nanocarriers of Silibinin

PEG-Modified <i>tert</i>-Octylcalix[8]arenes as Drug Delivery Nanocarriers of Silibinin

The hepatoprotective properties of silibinin, as well its therapeutic potential as an anticancer and chemo-preventive agent, have failed to progress towards clinical development and commercialization due to this material’s unfavorable pharmacokinetics and physicochemical properties, low aqueous solu...

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Bibliographic Details
Main Authors: Desislava Budurova, Denitsa Momekova, Georgi Momekov, Pavletta Shestakova, Hristo Penchev, Stanislav Rangelov
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceutics
Subjects:
calix[8]arenes
silibinin
inclusion complexes
PEGylation
cytotoxicity
Online Access:https://www.mdpi.com/1999-4923/13/12/2025

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https://www.mdpi.com/1999-4923/13/12/2025

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