Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity

Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity

IntroductionPlasmodium sporozoites (SPZ) inoculated by Anopheles mosquitoes into the skin of the mammalian host migrate to the liver before infecting hepatocytes. Previous work demonstrated that early production of IL-6 in the liver is detrimental for the parasite growth, contributing to the acquisi...

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Bibliographic Details
Main Authors: Selma Belhimeur, Sylvie Briquet, Roger Peronet, Jennifer Pham, Pierre-Henri Commere, Pauline Formaglio, Rogerio Amino, Artur Scherf, Olivier Silvie, Salaheddine Mecheri
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
IL-6
CD8 T cells
inflammation
liver
malaria
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1143012/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1143012/full

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