Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement

Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement

BackgroundLupus pathogenesis is mainly ascribed to increased production and/or impaired clearance of dead cell debris. Although self-reactive T and B lymphocytes are critically linked to lupus development, neutrophils, monocytes, and natural killer (NK) cells have also been implicated. This study as...

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Bibliographic Details
Main Authors: Bernadete L. Liphaus, Simone C. Silva, Patrícia Palmeira, Clovis A. Silva, Claudia Goldenstein-Schainberg, Magda Carneiro-Sampaio
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
anti-dsDNA
apoptosis
Bcl-2
Juvenile SLE
NK cells
nephritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1327255/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1327255/full

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