Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism

Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism

Abstract Histone acetylation involves the transfer of two-carbon units to the nucleus that are embedded in low-concentration metabolites. We found that lactate, a high-concentration metabolic byproduct, can be a major carbon source for histone acetylation through oxidation-dependent metabolism. Both...

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Bibliographic Details
Main Authors: Yong Jin An, Sihyang Jo, Jin-Mo Kim, Han Sun Kim, Hyun Young Kim, Sang-Min Jeon, Dawool Han, Jong In Yook, Keon Wook Kang, Sunghyouk Park
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-01095-w

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https://doi.org/10.1038/s12276-023-01095-w

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