The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation

The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation

Abstract Background Graft function may be affected if the organ is exposed to hypoxia. We hypothesized that bronchiolitis obliterans (BO) after lung transplantation is associated with hypoxia-inducible factor-1α (HIF-1α). This study compares the expression of HIF-1α and its downstream proteins in al...

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Bibliographic Details
Main Authors: Haichao Xu, Abudumailamu Abuduwufuer, Wang Lv, Zhenyu Zhou, Yunhai Yang, Chong Zhang, Jian Hu
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Cardiothoracic Surgery
Subjects:
Lung transplantation
Bronchiolitis obliterans
Fibrosis
Hypoxia-inducible factor 1, alpha subunit
Vascular endothelial growth factor a
Online Access:http://link.springer.com/article/10.1186/s13019-019-0832-z

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http://link.springer.com/article/10.1186/s13019-019-0832-z

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