A human stem cell-derived neuronal model of morphine exposure reflects brain dysregulation in opioid use disorder: Transcriptomic and epigenetic characterization of postmortem-derived iPSC neurons

A human stem cell-derived neuronal model of morphine exposure reflects brain dysregulation in opioid use disorder: Transcriptomic and epigenetic characterization of postmortem-derived iPSC neurons

IntroductionHuman-derived induced pluripotent stem cell (iPSC) models of brain promise to advance our understanding of neurotoxic consequences of drug use. However, how well these models recapitulate the actual genomic landscape and cell function, as well as the drug-induced alterations, remains to...

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Bibliographic Details
Main Authors: Emily F. Mendez, Sandra L. Grimm, Laura Stertz, Damian Gorski, Sai V. Movva, Katherine Najera, Karla Moriel, Thomas D. Meyer, Gabriel R. Fries, Cristian Coarfa, Consuelo Walss-Bass
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Psychiatry
Subjects:
epigenetic aging
RNAseq
induced pluripotent stem cells
postmortem brain
cocaine use disorder
opioid use disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1070556/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1070556/full

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