A Preclinical Investigation of GBM-N019 as a Potential Inhibitor of Glioblastoma via Exosomal mTOR/CDK6/STAT3 Signaling

A Preclinical Investigation of GBM-N019 as a Potential Inhibitor of Glioblastoma via Exosomal mTOR/CDK6/STAT3 Signaling

Glioblastoma (GBM) is one of the most aggressive brain malignancies with high incidences of developing treatment resistance, resulting in poor prognoses. Glioma stem cell (GSC)-derived exosomes are important players that contribute to GBM tumorigenesis and aggressive properties. Herein, we investiga...

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Bibliographic Details
Main Authors: Alexander T. H. Wu, Hsu-Shan Huang, Ya-Ting Wen, Bashir Lawal, Ntlotlang Mokgautsi, Thanh-Tuan Huynh, Michael Hsiao, Li Wei
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cells
Subjects:
GBM-N019
exosome
glioma stem cell
palbociclib
drug resistance
combination therapy
Online Access:https://www.mdpi.com/2073-4409/10/9/2391

Internet

https://www.mdpi.com/2073-4409/10/9/2391

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