Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin

Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin

Searching of new enantiomerically pure chiral derivatives of xanthones (CDXs) with potential pharmacological properties, particularly those with anti-inflammatory activity, has remained an area of interest of our group. Herein, we describe in silico studies and in vitro inhibitory assays of cyclooxy...

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Bibliographic Details
Main Authors: Carla Fernandes, Andreia Palmeira, Inês I. Ramos, Carlos Carneiro, Carlos Afonso, Maria Elizabeth Tiritan, Honorina Cidade, Paula C.A.G. Pinto, M. Lúcia M.F.S. Saraiva, Salette Reis, Madalena M.M. Pinto
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:Pharmaceuticals
Subjects:
chiral derivatives of xanthones
cyclooxygenase
albumin
enantioselectivity
docking
Online Access:http://www.mdpi.com/1424-8247/10/2/50

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http://www.mdpi.com/1424-8247/10/2/50

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