Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter

Abstract Multiple sclerosis (MS) is a disease of the central nervous system that is characterized by inflammation and focal areas of demyelination, ultimately resulting in axonal degradation and neuronal loss. Several lines of evidence point towards a role for microglia and other brain macrophages i...

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Bibliographic Details
Main Authors: Anneke Miedema, Emma Gerrits, Nieske Brouwer, Qiong Jiang, Laura Kracht, Michel Meijer, Erik Nutma, Regina Peferoen-Baert, Anna T. E. Pijnacker, Evelyn M. Wesseling, Marion H. C. Wijering, Hans-Joachim Gabius, Sandra Amor, Bart J. L. Eggen, Susanne M. Kooistra
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple sclerosis
Brain macrophages
Microglia
Single-cell RNAseq
Normal appearing white matter
Online Access:https://doi.org/10.1186/s40478-021-01306-3

Internet

https://doi.org/10.1186/s40478-021-01306-3

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