Xeno-Nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding

The causative agent of COVID-19, SARS-CoV-2, gains access to cells through interactions of the receptor-binding domain (RBD) on the viral S protein with angiotensin-converting enzyme 2 (ACE2) on the surface of human host cells. Systematic evolution of ligands by exponential enrichment (SELEX) was us...

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Bibliographic Details
Main Authors: Irani Alves Ferreira-Bravo, Jeffrey J. DeStefano
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/13/10/1983