Lipidic Aminoglycoside Derivatives: A New Class of Immunomodulators Inducing a Potent Innate Immune Stimulation

Lipidic Aminoglycoside Derivatives: A New Class of Immunomodulators Inducing a Potent Innate Immune Stimulation

Abstract Development of simple and fully characterized immunomodulatory molecules is an active area of research to enhance current immunotherapies. Monophosphoryl lipid A (MPL), a nontoxic lipidic derivative from bacteria, is the first and currently only adjuvant approved in humans. However, its cap...

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Bibliographic Details
Main Authors: Thibault Colombani, Thomas Haudebourg, Marion Decossas, Olivier Lambert, Grace Ada Da Silva, Frederic Altare, Bruno Pitard
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:Advanced Science
Subjects:
adjuvants
cationic lipids
immunotherapy
lipoaminoglycosides
phosphatidylinositol phospholipase C (PLC)
Online Access:https://doi.org/10.1002/advs.201900288

Internet

https://doi.org/10.1002/advs.201900288

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